MLZ

Dr. Medel Manuel L. Zulueta

Position: Associate Professor

Education: Ph.D. Chemistry, University of the Philippines, Diliman, Quezon City
                     BS Chemistry, Polytechnic University of the Philippines, Santa Mesa, Manila

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Research Homepage:                                                                                                                                   

POST DOCTORAL TRAINING:

Post-doctoral Fellow, Shang-Cheng Hung’s laboratory at the Genomics Research Center, Academia Sinica, Taipei, Taiwan

 

FIELD OF SPECIALIZATION / RESEARCH INTEREST:

Carbohydrate synthesis. Interested in carbohydrate structures, the development of strategies for their chemical preparation as well as the evaluation of their structure–activity relationships.

REPRESENTATIVE PUBLICATIONS:

1. Huang, T.-Y., Irene, D., Zulueta, M. M. L., Tai, T.-J., Lain, S.-H., Cheng, C.-P., Tsai, P.-X., Lin, S.-Y., Chen, Z.-G., Ku, C.-C., Hsiao, C.-D., Chyan, C.-L. & Hung, S.-C. Structure of the complex between a heparan sulfate octasaccharide and mycobacterial heparin‐binding hemagglutinin. Angewandte Chemie, International Edition 56, 4192–4196 (2017).
2. Hung, S.-C. & Zulueta, M. M. L. (Eds). Glycochemical Synthesis: Strategies and Applications; Wiley, 2016.
3 Liang, W. G., Triandafillou, C. G., Hwang, T.-Y., Zulueta, M. M. L., Banerjee, S., Dinner, A. R., Hung, S.-C. & Tang, W.-J. Structural basis for oligomerization and glycosaminoglycan-binding of CCL5 and CCL3. Proceedings of the National Academy of Sciences of the United States of America, 113, 5000– 5005 (2016).
4 Ho, G.-M., Huang, C.-J., Li, E. Y.-T., Hsu, S.-K., Wu, T., Zulueta, M. M. L., Wu, K. & Hung, S.-C. Unconventional exo selectivity in thermal normal-electron-demand Diels–Alder reactions. Scientific Reports 6, doi: 10.1038/srep35147 (2016).
5. Zulueta, M. M. L. & Hung, S.-C. Synthesis of sulfated glycans. Glycoscience: Biology and Medicine; Taniguchi, N., Endo, T. Hart, G. W., Seeberger, P. H. & Wong, C.-H. (Eds). Springer: Japan, pp 365–371 (2015).
6. Patil, P. S., Cheng, T.-J. R., Zulueta, M. M. L., Yang, S.-T., Lico, L. S., Hung, S.-C. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. Nature Communications 6, doi: 10.1038/ncomms8239 (2015).
7. Zulueta, M. M. L., Janreddy, D. & Hung, S.-C. One-pot methods for the protection and assembly of sugars. Israel Journal of Chemistry 55, 347–359 (2015) (chosen as cover image for the issue).
8. Huang, T.-Y., Zulueta, M. M. L. & Hung, S.-C. Regioselective one-pot protection, protection–glycosylation and protection–glycosylation–glycosylation of carbohydrates: a case study with D-glucose. Organic and Biomolecular Chemistry 12, 376–382 (2014).
9. Zulueta, M. M. L., Lin, S.-Y., Hu, Y.-P. & Hung, S.-C. Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions. Current Opinion in Chemical Biology 17, 1023–1029 (2013).
10. Zulueta, M. M. L., Lin, S.-Y. & Hung, S.-C. Chemical synthesis of oligosaccharides based on heparin and heparan sulfate. Trends in Glycoscience and Glycotechnology 25, 141–158 (2013).
11. Zulueta, M. M. L., Zhong, Y.-Q. & Hung, S.-C. Synthesis of L-hexoses and their related biomolecules. Chemical Communications 49, 3275–3287 (2013).
12. Zulueta, M. M. L., Lin, S.-Y., Lin, Y.-T., Huang, C.-J., Wang, C.-C., Ku, C.-C., Shi, Z., Chyan, C.-L., Irene, D., Lim, L.-H., Tsai, T.-I., Hu, Y.-P., Arco, S. D., Wong, C.-H. & Hung, S.-C. α-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin. Journal of the American Chemical Society 134, 8988–8995 (2012).
13. Hsu, Y., Lu, X.-A., Zulueta, M. M. L., Tsai, C.-M., Lin, K.-I., Hung, S.-C. & Wong, C.-H. Acyl and silyl group effects in reactivity-based one-pot glycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4 and IV2Fuc-Lc4. Journal of the American Chemical Society 134, 4549–4552 (2012).
14. Lee, I.-C., Zulueta, M. M. L., Shie, C.-R., Arco, S. D. & Hung, S.-C. Deuterium-isotope study on the reductive ring opening of benzylidene acetals. Organic and Biomolecular Chemistry 9, 7655–7658 (2011).
15. Hu, Y.-P., Lin, S.-Y., Huang, C.-Y., Zulueta, M. M. L., Liu, J.-Y., Chang, W. & Hung, S.-C. Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction. Nature Chemistry 3, 557–563 (2011).