Dr. Medel Manuel L. Zulueta

Position: Associate Professor

Education: Ph.D. Chemistry, University of the Philippines, Diliman, Quezon City
                     BS Chemistry, Polytechnic University of the Philippines, Santa Mesa, Manila

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Research Homepage:                                                                                                                                   


Post-doctoral Fellow, Shang-Cheng Hung’s laboratory at the Genomics Research Center, Academia Sinica, Taipei, Taiwan



Carbohydrate synthesis. Interested in carbohydrate structures, the development of strategies for their chemical preparation as well as the evaluation of their structure–activity relationships.


1. Huang, T.-Y., Irene, D., Zulueta, M. M. L., Tai, T.-J., Lain, S.-H., Cheng, C.-P., Tsai, P.-X., Lin, S.-Y., Chen, Z.-G., Ku, C.-C., Hsiao, C.-D., Chyan, C.-L. & Hung, S.-C. Structure of the complex between a heparan sulfate octasaccharide and mycobacterial heparin‐binding hemagglutinin. Angewandte Chemie, International Edition 56, 4192–4196 (2017).
2. Hung, S.-C. & Zulueta, M. M. L. (Eds). Glycochemical Synthesis: Strategies and Applications; Wiley, 2016.
3 Liang, W. G., Triandafillou, C. G., Hwang, T.-Y., Zulueta, M. M. L., Banerjee, S., Dinner, A. R., Hung, S.-C. & Tang, W.-J. Structural basis for oligomerization and glycosaminoglycan-binding of CCL5 and CCL3. Proceedings of the National Academy of Sciences of the United States of America, 113, 5000– 5005 (2016).
4 Ho, G.-M., Huang, C.-J., Li, E. Y.-T., Hsu, S.-K., Wu, T., Zulueta, M. M. L., Wu, K. & Hung, S.-C. Unconventional exo selectivity in thermal normal-electron-demand Diels–Alder reactions. Scientific Reports 6, doi: 10.1038/srep35147 (2016).
5. Zulueta, M. M. L. & Hung, S.-C. Synthesis of sulfated glycans. Glycoscience: Biology and Medicine; Taniguchi, N., Endo, T. Hart, G. W., Seeberger, P. H. & Wong, C.-H. (Eds). Springer: Japan, pp 365–371 (2015).
6. Patil, P. S., Cheng, T.-J. R., Zulueta, M. M. L., Yang, S.-T., Lico, L. S., Hung, S.-C. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. Nature Communications 6, doi: 10.1038/ncomms8239 (2015).
7. Zulueta, M. M. L., Janreddy, D. & Hung, S.-C. One-pot methods for the protection and assembly of sugars. Israel Journal of Chemistry 55, 347–359 (2015) (chosen as cover image for the issue).
8. Huang, T.-Y., Zulueta, M. M. L. & Hung, S.-C. Regioselective one-pot protection, protection–glycosylation and protection–glycosylation–glycosylation of carbohydrates: a case study with D-glucose. Organic and Biomolecular Chemistry 12, 376–382 (2014).
9. Zulueta, M. M. L., Lin, S.-Y., Hu, Y.-P. & Hung, S.-C. Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions. Current Opinion in Chemical Biology 17, 1023–1029 (2013).
10. Zulueta, M. M. L., Lin, S.-Y. & Hung, S.-C. Chemical synthesis of oligosaccharides based on heparin and heparan sulfate. Trends in Glycoscience and Glycotechnology 25, 141–158 (2013).
11. Zulueta, M. M. L., Zhong, Y.-Q. & Hung, S.-C. Synthesis of L-hexoses and their related biomolecules. Chemical Communications 49, 3275–3287 (2013).
12. Zulueta, M. M. L., Lin, S.-Y., Lin, Y.-T., Huang, C.-J., Wang, C.-C., Ku, C.-C., Shi, Z., Chyan, C.-L., Irene, D., Lim, L.-H., Tsai, T.-I., Hu, Y.-P., Arco, S. D., Wong, C.-H. & Hung, S.-C. α-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin. Journal of the American Chemical Society 134, 8988–8995 (2012).
13. Hsu, Y., Lu, X.-A., Zulueta, M. M. L., Tsai, C.-M., Lin, K.-I., Hung, S.-C. & Wong, C.-H. Acyl and silyl group effects in reactivity-based one-pot glycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4 and IV2Fuc-Lc4. Journal of the American Chemical Society 134, 4549–4552 (2012).
14. Lee, I.-C., Zulueta, M. M. L., Shie, C.-R., Arco, S. D. & Hung, S.-C. Deuterium-isotope study on the reductive ring opening of benzylidene acetals. Organic and Biomolecular Chemistry 9, 7655–7658 (2011).
15. Hu, Y.-P., Lin, S.-Y., Huang, C.-Y., Zulueta, M. M. L., Liu, J.-Y., Chang, W. & Hung, S.-C. Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction. Nature Chemistry 3, 557–563 (2011).